Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1
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چکیده
منابع مشابه
Genipin attenuates sepsis by inhibiting Toll-like receptor signaling.
The pathogenesis of sepsis is characterized by overwhelming inflammatory responses that lead to tissue damage and organ failure. Toll-like receptor (TLR) signaling is crucial for induction of hyperinflammatory responses and tissue injury during sepsis. Genipin, an aglycon of geniposide, has antiinflammatory and antimicrobial activities. The purpose of this study was to test the hypothesis that ...
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BACKGROUND Major depressive disorder is characterized as persistent low mood. A chronically stressful life in genetically susceptible individuals is presumably the major etiology that leads to dysfunctions of monoamine and hypothalamus-pituitary-adrenal axis. These pathogenic factors cause neuron atrophy in the limbic system for major depressive disorder. Cell-specific pathophysiology is unclea...
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Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated that repeated restraint stress disrupts the activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. The behavioral and neurochemica...
متن کاملThe effect of mental exercise and Nepeta menthoides on depression-like behavior induced by reserpine in the rat
Background and Objective: Many studies demonstrate that cognitive empowerment reduces the risk of depression. Anti-depressant properties of Nepeta menthoides has also been reported. This study aimed to determine the effects of mental exercise and Nepeta menthoides and also to compare both of them on reserpine-induced depression in rats. Materials and Methods: Male rats were divided into 8 grou...
متن کاملLeonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation
Background Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. Emerging evidence indicates that leonurine produces neuroprotective effects in ischemic stroke, Parkinson's disease, and Alzheimer's disease. However, the effect of leonurine in neuropsychiatric disorders, especially in major depression, remains unknown. Methods We used the chronic mi...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2018
ISSN: 1559-2294,1559-2308
DOI: 10.1080/15592294.2018.1450033